The use of histafen in the complex treat-ment of patients with senile itching

  • Анатолий Дюдюн доктор медицинских наук, профессор, заведующий кафедрой кожных и венерических болезней ГУ «Днепропетровская медицинская академия Министерства здравоохранения Украины»
  • Наталья Полион кандидат медицинских наук, доцент, кафедра кожных и венерических болезней ГУ «Днепропетровская медицинская академия Министерства здравоохранения Украины»
Keywords: Histafen, Loratodine, senile pruritus, therapeutic efficacy

Abstract

The purpose of the work is to evaluate the efficacy and tolerability of the drug Histafen (sechifenadine) in com­parison with the drug Loratodin in patients with senile itching.

Materials and research methods. Under our supervision there were 60 patients over the age of 50 years. Clinical and laboratory examination and dynamic observation consisted of conducting a general clinical ex­amination and treatment of thematic patients with a sub­sequent analysis of the results. 30 patients of the main group who were prescribed with Histafen (sechifenadine) and 30 patients of the comparison group treated with Lor- atodine have been included in the complex treatment with the use as a blocker of histamine H1-receptors and sero­tonin 5-HT1-receptors. Histafen was prescribed 1 tablet twice a day, Loratadine - 1 tablet once a day. The ob­served patients took both drugs for 14 days.

Results and its discussion. When assessing the therapeutic effect in patients of the main group as a result of the therapy with the Histafen drug, “excellent improvement” was regis­tered in 10 (33.33 %) cases, “good improvement” - in 18 (60.0 %), and “moderate improvement” - in 2 (6.67 %); “no improvement” and “deterioration” were not marked.

Conclusions. The use of the drug Histafen in the treat­ment of patients with senile itching made it possible to achieve pronounced positive dynamics with rapid relief of subjective symptoms.

References

1. Калюжная Л.Д., Мурзина Э.А., Турик Н.В., Савкина Н.И. Гистафен в лечении аллергодерматозов. Український журнал дерматології, венерології, косметології. 2008. № 1. С. 5-7.
2. Хаитов Р.М. Клиническая аллергология. Руководство для практических врачей. М., 2002. С. 500-527.
3. Яцемирская Р.С. Социальная геронтология. М., 2003. 53 с.
4. Agraval D.K. Pharmacology and clinical efficacy of desloratadine as an antiallergic and antiin- flamatory drug. Exp. Invest. Drugs. 2001. Vol.
10, No 3. P. 547-560.
5. Arnold L.M., Auchenbach M.B., McElroy S.L. Psychogenic excoriation: clinical features, proposed diagnostic criteria, epidemiology, and approaches to treatment. CNS Drugs. 2001. Vol. 15. P. 351-359.
6. Canonica G. W., Blaiss M. Antihistaminic, AntiInflammatory, and Antiallergic Properties of the Nonsedating Second-Generation Antihistamine Desloratadine: A Review of the Evidence World Allergy Organ J. 2011 Vol. 4, No 2. Р. 47-53.
7. DuBuske L. Second generation antihistamies: the risk of ventricular arrhythmias. Clin. Ther. 1999. Vol. 21, No 2. P. 281-285.
Published
2019-11-28
How to Cite
Дюдюн, А., & Полион, Н. (2019). The use of histafen in the complex treat-ment of patients with senile itching. Dermatovenerology. Cosmetology. Sexopathology, (3-4), 65-69. https://doi.org/10.37321/dermatology.2019.3-4-11